Primate models of neurological disorders

Cover of: Primate models of neurological disorders |

Published by Raven Press in New York .

Written in English

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  • Nervous system -- Diseases -- Animal models.,
  • Primates as laboratory animals.

Edition Notes

Includes bibliographies and index.

Book details

Statementeditors, B. S. Meldrum, C. D. Marsden.
SeriesAdvances in neurology ;, v. 10
ContributionsMeldrum, Brian S., Marsden, C. David.
LC ClassificationsRC347 .P74
The Physical Object
Paginationxvi, 362 p. :
Number of Pages362
ID Numbers
Open LibraryOL5058482M
ISBN 100890040028
LC Control Number74021980

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Primate models of human neurogenic disorders Hardcover – by V. G Start͡s︡ev (Author)Cited by: 1. Stereotaxic lesions and movement disorders in monkeys --Tremorgenic mechanisms in primates --Sterotaxic technique for stimulation and recording in nonanesthetized monkeys: application to the determinatin of connections between caudate and substantia nigra --Drug-induced dyskinesia in monkeys --Primate models of postural abnormalities --Experimental models of oculomotor dysfunciton in the rhesus monkey --Cortical control of motor prostheses: using the cord-transected baboon as the primate.

Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by : P. Thomas. This is a PDF-only article.

The first page of the PDF of this article appears : P. Thomas. A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species.

Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models Missing: neurological disorders.

Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor function, to assess the impact of disease and injury on sensory and motor function, and to test candidate therapies before they are applied to human patients.

The lesion model consists Cited by: In addition to studying the uninjured primate central nervous system and spontaneous responses to injury, we have used this nonhuman primate model of SCI to study responses to promising regenerative therapeutic interventions derived from rodent models of SCI, including cellular transplantation strategies [23, 26] and growth factor gene delivery [24, 25].Cited by:   A wide range of animal models including worms, fruit flies, zebrafish, and rodents have been used to study neural development and disorders.

However, whether complicated neurological and psychiatric symptoms can be faithfully mimicked in animals other than primates is still by: 6. Huntington’s disease is a neurological disorder characterized by loss of striatal neurons and the motor signs of dyskinesia, dystonia, and chorea, as well as complex neuropsychiatric changes (Hayden ).

Brouillet et al. () reviewed the different aspects of the replicating Huntington’s disease phenotype in experimental animals.

Of primary concern to an investigator of neurological disorders is that of the selection of the most relevant animal model to achieve his or her research goals. According to Kornetsky (), three different types of animal models are typically used in medical : Kathryn G. Todd, Roger F.

Butterworth. Nout et al. describe a novel model of cervical spinal cord injury and forelimb control in the nonhuman primate that provides a basis for studies of regeneration and functional recovery of arm and hand by: Additional Physical Format: Online version: Start︠s︡ev, V.G.

(Valentin Georgievich). Primate models of human neurogenic disorders. Hillsdale, N.J.: L. Erlbaum. Animal Models of Neurological Disorders. In book: In Vivo Neuromethods, pp A primate model of Parkinsonism-selective destruction of dopaminergic-neurons in the pars compacta of the.

This “Animal Models of Neurological Disorders—Principle and Working Procedure for Animal Models of Neurological Disorders” book is introduced for the first time and contains detailed information on different types of animal models of neurological disorders along with working principle, experimental procedure, different neurotoxins with doses, and.

The nonhuman primate models have provided an opportunity to investigate developmental and neurological changes. This chapter analyzes the status of developmental disabilities in humans, the current status of nonhuman primate models for lentivirus infection, and how they have been utilized to study developmental disabilities, and potential treatments and vaccines designed to.

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures.

Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes Price: $   Primate Models of Children's Health and Developmental Disabilities - Ebook written by Thomas Burbacher, Kimberly Grant, Gene P.

Sackett. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Primate Models of Children's Health and.

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders.

Because of increasing public concern over the ethical treatment of animals in research, we felt it. American veterinary Medical Association () J. Vet. Med. Assoc.– Google ScholarCited by: 1. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important.

Title:Beyond Rodent Models of Pain: Non-Human Primate Models for Evaluating Novel Analgesic Therapeutics and Elaborating Pain Mechanisms. VOLUME: 12 ISSUE: 8. Author(s):Aldric T. Hama, Katsuo Toide and Hiroyuki Takamatsu. Affiliation:Hamamatsu Pharma Research, Kita-ku, Shinmiyakoda, HamamatsuJapan.

Large Animal Models of Neurological Disorders for Gene Therapy Christine Gagliardi and Bruce A. Bunnell Christine Gagliardi, BS, is a student in the Graduate Program in Biomedical Sciences at Tulane University in New by:   Nonhuman Primate Models of Neurodegenerative Disorders.

Marina E. Emborg, MD, PhD, is the director of the Preclinical Parkinson’s Research Program at the Wisconsin National Primate Research Center and an associate professor in the department of Medical Physics at the University of Wisconsin in Madison, by: 5. Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies.

PRIMATE MODELS OF NEUROLOGICAL DISORDERS (Advances In Neurology, Volume 10) By P. Thomas Topics: Book ReviewsAuthor: P. Thomas. Additional brain regions important in other neurological disorders could also be considered for profiling (e.g., hippocampus, entorhinal cortex, amygdala, striatum).

Finally, our analyses of genes known to be important in neurological disorders validate some experimental models while indicating the context where these models are most by:   The most recent references date to /7, and this is a rapidly developing field; but the reviews are sufficiently broad and informative that this should not make the book dated.

`Cell Transplantation for Neurological Disorders' provides a sound basis for understanding upcoming new research findings, especially for interpreting and applying Cited by: 1. Consequently, this decade has seen the generation of a transgenic rhesus monkey 3 and the first primate model of a human disorder, Huntington's disease, also in Cited by: This review discusses non-human primate models of multiple sclerosis (MS), a progressive neurological disorder with a high unmet need for effective treatment.

These models can help to bridge the gap between rodent experimental autoimmune encephalomyelitis (EAE) models and patients, which is a main cause of the present high attrition rate of new Cited by: 2.

Because of the unique structure and function of the primate brain, it is impossible to gain a full, accurate understanding of either normal human brain function or mental illness (neurological and psychiatric disorders) through rodent-based by: The primate model of perinatal asphyxia The study of perinatal asphyxia was advanced by a model in newly delivered monkeys.

Immediately after delivery before breathing could be initiated, the umbilical cord was clamped, and the newborn head was immersed in a plastic bag full of warm saline. These studies while appearing heartless established the. Buy Animal and Translational Models for CNS Drug Discovery: Neurological Disorders: Read Kindle Store Reviews - Animal and Translational Models for CNS Drug Discovery: Neurological Disorders - Kindle edition by Robert A.

McArthur, Franco Borsini. Primate Models of Children's Health and Developmental Disabilities: Medicine & Health Science Books @ mental retardation, hearing loss and attention deficit hyperactivity disorder is rising in the United States.

Although estimates of the prevalence of these disorders vary, figures from the CDC indicate that 4% of Author: Thomas Burbacher. THE NATIONAL ACADEMIES PRESS Fifth Street, NW Washington, DC WALTER KOROSHETZ, National Institute of Neurological Disorders and Stroke.

JOHN MORRISON, University of California, 3 STATE OF THE SCIENCE OF TRANSGENIC NONHUMAN PRIMATE MODELS FOR NERVOUS SYSTEM DISORDERS. Genetically Modified Nonhuman Primate Models. Microarray analysis of nonhuman primates: Validation of experimental models in neurological disorders Article in The FASEB Journal 17(8).

Suggested Citation:"Appendix C: Registered Attendees." National Academies of Sciences, Engineering, and Medicine. Transgenic Neuroscience Research: Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop.

Washington, DC: The National Academies. Animal Models for Neurological Disorders. Patricia F. Fitzpatrick Dimond - Janu 0. Walker LC.

Nonhuman primate models of Alzheimer-like cerebral proteopathy. Curr Pharm Des. Generation of genetically engineered non‐human primate models of brain function and neurological disorders Jung Eun Park Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MarylandCited by: 2.

MAI DANG, YUQING LI, in Animal Models of Movement Disorders, For elucidating protein function and a mutant protein's role in producing neurological pathology, a mouse model can provide essential information. Other systems, such as yeast, worm, fly, and zebrafish, have proven to be useful genetic tools that are sometimes created and.

Generation of genetically engineered non‐human primate models of brain function and neurological disorders. Jung Eun Park. Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland Cited by: 2.

Newly created transgenic primate may become an alternative disease model to rhesus macaques. Download PDF Erika Sasaki (centre) with transgenic marmosets Hisui, Banko, Wakaba, Kei and by: Generation of genetically engineered non‐human primate models of brain function and neurological disorders Article (PDF Available) in American Journal of Primatology 81(8) December with.drugs for nervous system disorders that show efficacy in rodent models fail in human clinical trials (Kola and Landis, ).Given the many recent failures of rodent-based treatments for neurological disease to translate to humans in clinical trials, neuroscientists are giving increasing thought to approaches to therapeutic development that do not rely on rodent models (see.

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